We immunohistochemically analyzed Nm23/NDPK-A in 96 cases, a larger sample size than that of Nakamori et al. Our findings also indicated higher Nm23/NDPK-A expression levels to be associated with poor prognosis, but there was no significant correlation with lymph node metastasis. Here, NME1 is linked to metastatic malignant neoplasm in the lymph nodes.