In contrast, strong expression of TLR2, TLR4 and RAGE was observed in renal biopsies from patients with active LN compared to control renal tissue, with 28.7 (24.7 to 50.0%), P < 0.008, for TLR2; 28.8% (20 to 40%), P < 0.008, for TLR and 29% (17 to 40%), P < 0.008, for RAGE. Here, TLR4 is linked to lobular neoplasia.