Commercial milk intake by increasing plasma concentrations of insulin, IGF-1, leucine, estrogens and androgen-precursors may amplify preexistent high mTORC1 signaling due to genetic alterations of the PI3K/PTEN/Akt/Rheb/mTORC1 pathway of PCa cells (Figure5). The gene discussed is RHEB; the disease is posterior cortical atrophy.