BCAT2 and obesity due to melanocortin 4 receptor deficiency: In obesity and states of insulin resistance, elevated BCAA have been associated with reduced expression of two adipose tissue BCAA catalytic enzymes: mitochondrial branched-chain aminotransferase 2 (BCAT2) and branched-chain α-keto acid dehydrogenase (BCKD E1α subunit) complex[197-199].