Based on its role in mesodermal development during mammalian embryogenesis [8,9], TWIST1 is proposed to induce an embryonic event termed epithelial-mesenchymal transition (EMT) in tumor cells to promote the expression of mesenchymal junction proteins in epithelial cells and reduce intercellular junctions in the meantime [2,10,11]. Here, TWIST1 is linked to neoplasm.