As both IL-1β and IL-23 have been shown to be expressed at higher levels by monocyte derived dendritic cells from CAPS patients (Lasiglie et al., 2011), this further indicates that γδ T cell subsets may provide an important innate source of IL-17 related cytokines in autoinflammatory disease. The gene discussed is IL1B; the disease is cryopyrin-associated periodic syndrome.