The spontaneous hypertensive rat, which displays both ventriculomegaly (Ruchoux et al., 1992) and signs of altered dopaminergic signaling (van den Buuse, 2004), could also be an especially relevant animal model to scrutinize in the context of the CP–CSF nexus and ventricular enlargement in schizophrenia. The gene discussed is CP; the disease is schizophrenia.