The mechanism of alleviation of hypertension-induced cognitive deficits by angiotensin receptor type 1 blockers (the sartans) most probably involves their ability to stimulate peroxisome proliferator-activated receptor gamma (PPAR-γ) (Fournier et al. 2009; Saxby et al. 2008; Schrader et al. 2007; Trenkwalder 2006). This evidence concerns the gene PPARG and Hypertension.