EGFR and non-small cell lung carcinoma: These mutations can be grouped into two main categories: a) kinase activating mutations similar to those found in EGFR in NSCLC and Head & Neck cancer; b) single aminoacid mutatations in domain II or IV of the extracellular domain which affect the intramolecular contact between these two domains and induce a shift towards a constitutively open conformation of the receptor [72].