The increasing awareness for the innate immune system and its possible role in the CNS is documented in recent publications (cited in [7,8]): Mannan-binding lectin (MBL) [7] is of increasing clinical interest, since MBL deficiency [8] was found to be associated with different diseases, including infections, in systemic as well as neurological diseases [8-11]. This evidence concerns the gene MBL2 and hyperinsulinemic hypoglycemia, familial, 4.