MDM2 and neoplasm: In this latter case, the use of the small molecule RITA (reactivation of p53 and induction of tumor cell apoptosis) that inhibits MDM2/p53 interaction and induces expression of p53 target genes and massive apoptosis in various tumor cells lines [35], can be useful to counteract HIPK2 degradation and to reactivate p53 apoptotic function [38].