Futhermore, in a multivariate Cox model, including tumor size, tumor stage, tumor grading, presence of cirrhosis, gender, age, and L1CAM staining, we found that L1CAM expression was an independent poor prognostic factor for both 5-year disease-free survival (hazards ratio [HR] = 2.279, 95% confidence interval[CI] = 1.185-5.697, P = 0.02, Table 2) and 5-year overall survival (HR = 3.269, CI = 1.136-7.328, P = 0.008, Table 2) in HCC. This evidence concerns the gene L1CAM and hepatocellular carcinoma.