A glucose-regulated protein (GRP94), albumin in a complex with myristic acid and tri-iodobenzoic acid, the tropomyosin alpha-4, the 14-3-3 protein zeta/delta, the apolipoprotein A-I, and the orosomucoid-1 protein were up-regulated in OM. The gene discussed is ORM1; the disease is ocular melanoma.