Lenalidomide induces NK cells to produce granulocyte-macrophage colony-stimulating factor (GM-CSF), TNF-α, and various immune recruiting chemokines including RANTES, IL-8, MCP-1, and MIP-1α/β in response to antibody-coated tumor cell lines, which contributes to a more effective immune response [65]. This evidence concerns the gene CSF2 and neoplasm.