IDH1 and acute myeloid leukemia: Since these initial reports, mutations in IDH1 and IDH2 have been identified in 16-17% of patients with acute myeloid leukemia, in 20% of angioimmunoblastic T-cell lymphomas [26], and spotted in a variety of other malignancies at lower frequencies [27, 28] such as B-acute lymphoblastic leukemias, thyroid, colorectal, and prostate cancer [29, 30].