GNRHR and hypogonadotropic hypogonadism: Beate and colleagues in their paper “Genetics of isolated hypogonadotropic hypogonadism: role of GnRH receptor and other genes” showed an interesting revision about the genetics of isolated hypogonadotropic hypogonadism and the importance of inactivating mutations in the pituitary GnRH receptor inducing GnRH resistance in patients with normosmic isolated hypogonadotropic hypogonadism.