To develop a more physiological assay for polyclonal IgE, Kashiwakura et al. (2009) injected mice with a mixture of the house dust mite antigen (Der f) and S. aureus enterotoxin B (a T cell superantigen) to stimulate a vigorous IgE response, an approach designed to provide a model of AD (Kawakami et al., 2007). Here, IGHE is linked to Alzheimer disease.