Cytokinergic IgE activity may provide a rationale for the paradoxical observation that the risk of developing an “allergic disease” and severity of the disease is more closely related to the levels of total IgE than allergen-specific IgE in serum (Burrows et al., 1989; Sunyer et al., 1996; Beeh et al., 2000). Here, IGHE is linked to allergic disease.