To examine the relationship between cytokinergic IgE activity and polyreactivity Kashiwakura et al. (2012b) tested a number of well characterized mouse and human HC and PC IgEs for binding to a panel of autoantigens routinely used for the diagnosis of autoimmunity (single- and double-stranded DNA, thyroglobulin, β-galactosidase) and HRF. The gene discussed is IGHE; the disease is Autoimmunity.