To obtain complete immunosuppressive effects, the inhibition of more than PKCθ appears to be needed, and the pharmacologic inhibition of multiple PKC isotypes may provide a successful approach to avert T cell effector functions that are relevant for diseases such as psoriasis, atopic dermatitis, and allergies, as well as other indications, including asthma, rheumatoid arthritis, multiple sclerosis, and transplant rejections. The gene discussed is PRRT2; the disease is multiple sclerosis.