Our most significant gene, MACROD2, which we also replicated in a new cohort, was recently discovered in the context of autism spectrum disorder (ASD), as the gene containing the top SNP (p < 5 × 10−8) in a GWAS of 1,558 families of whom some members had been diagnosed with ASD (Anney et al., 2010). This evidence concerns the gene MACROD2 and autism spectrum disorder.