In the context of shigellosis, the well-defined histopathology of this animal model (Fig 5A and B) mirrors the clinical observation that the IL-6- and IL-8-mediated inflammatory response in shigellosis is localized to the gut (Coron et al, 2009; Islam et al, 1994; Schnupf & Sansonetti, 2012; Sperandio et al, 2008). This evidence concerns the gene CXCL8 and shigellosis.