Infiltration of the surface epithelium and lamina propria by γδ+ CD4+ and CD8+ T-cells occurs in human shigellosis (Islam & Christensson, 2000; Raqib et al, 1994) with CD3+CD4+FoxP3+ T regulatory (Treg) cells maintaining gut tolerance by suppressing local antigen specific immune responses to commensal bacteria (Sellge et al, 2010). This evidence concerns the gene CD4 and shigellosis.