MYC and medulloblastoma: Yet c-Myc protein levels remained unchanged in all three tested medulloblastoma cell lines: D283, Daoy and UW288, despite of successful c-Myc overexpression in HO15.19 cells (Supporting Information Fig S4; c-Myc was undetectable in naive HO15.19 cells) and many other cell lines using the same plasmid or its derivatives (Ricci et al, 2004).