Also, non-canonical TGF-β signaling results in aortic aneurysm in MFS mice [Holm et al., 2011] that was prevented by TGF-β neutralizing antibody or the angiotensin II type 1 receptor (AT1) blocker, losartan [Habashi et al., 2006]. This evidence concerns the gene TGFB1 and aortic aneurysm.