Additionally, the direct correlation of the genes involved in glycolysis such as FBP2, GPD1, PDK2, and PKM2 with metabolites in clusters-7A and 7B (Fig. S4-7a, b in the “Electronic Supplementary Material”) is consistent with the inhibition of glycolysis in orlistat-treated NSCLC cells. This evidence concerns the gene PKM and non-small cell lung carcinoma.