GLI2 and cholestasis: However, both genes showed a slightly lower basal line expression in Mx1-Cre;Yapflox/flox, compared to control Yapflox/flox, mice (Fig. 7).6, 46 Similarly, there was no difference between Yapflox/flox control and Mx1-Cre;Yapflox/flox at any of the time points after BDL for the Hedgehog target genes, Gli2 or FoxL1, both of which have been reported to be critical in cholestasis-mediated bile duct proliferation (Fig. 7).7, 9