Böttcher et al. [16] showed that non-diabetic homozygous carriers of the obesity risk alleles for rs7922846 (c.67 + 5659A) and three other BMPR1A variants (rs7095025, rs11202222, and rs10788528) had higher visceral and subcutaneous adipose tissue mRNA expression of BMPR1A, yet only rs7922846 was significantly associated with increased visceral mRNA expression [16]. The gene discussed is BMPR1A; the disease is obesity due to melanocortin 4 receptor deficiency.