This finding seems also to indicate that rapamycin and RAD-001 effects are not superimposable, as rapamycin treatment of T-ALL cell lines, under the same conditions employed here as for RAD-001, did not result in Ser 473 p-Akt dephosphorylation in the same T-ALL cell lines [21]. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.