APOE genotype also has been associated with disease risk or clinical outcome of other neurodegenerative diseases such as vascular dementia, Parkinson’s disease, and dementia with Lewy bodies as described in a recent review [11], suggesting mechanisms, in addition to modulation of Aβ trafficking, by which apoE isoforms may influence neurodegenerative processes. This evidence concerns the gene APOE and neurodegenerative disease.