One group has reported that apoC-I mRNA is consistently lower in frontal cortex of brains from control and AD patients that harbor the APOC1 H2 allele (usually inherited with APOE ε4) compared with patients with the APOC1 H1 allele (usually inherited with APOE ε3); however, while human brain regional apoC-I protein in controls was also lower in association with APOC1 H2 allele the opposite association was observed in patients with AD [26]. Here, APOE is linked to Alzheimer disease.