Duplications of MECP2 have been described as the cause of Lubs syndrome (OMIM #300260), an X-linked recessive disorder in which affected males manifest a variety of moderate to severe neurological and cognitive phenotypes, including hypotonia, delayed or absent speech, intellectual disabilities, epilepsy, late-onset spasticity, as well as feeding difficulties and recurrent respiratory infections [2-7]. The gene discussed is MECP2; the disease is Intellectual disability.