Specifically, subgroup analysis of ARDS Network data has shown significantly lower levels of serum biomarkers (von Willebrand factor antigen [vWF], surfactant protein D [SP-D], tumor necrosis factor receptor-1 [TNFr-1], and intercellular adhesion molecule-1 [ICAM-1], associated with poor outcome in trauma patients [19]. Here, TNFRSF1A is linked to acute respiratory distress syndrome.