PARP1 and neoplasm: In fact, it is now recognised that inhibition of PARPs leads to impairment of DNA double-strand-break repair, enhancing the cytotoxic effects of ionizing radiation and DNA-damaging chemotherapeutic agents.16,89,90 In addition, CAF-1/p60 has recently emerged as a promising target, inhibition of which could lead to cell death in aggressive tumours.32–36 This hypothesis has been further supported by the results of the cell death assay on HaCat and CAL33 cells that we performed with CAF-1 p60 siRNA and the PARP-1 inhibitor PJ34.