It is possible that MCMV-specific, effector CD8+ T cells and CD4+ T cells contribute IL-10 in the liver during this infection, although further characterization of IL-10+ T cells at this site is necessary as regulatory subsets of CD4+ T cells [50] and CD8+ T cells [51], [52] have been shown to also generate IL-10 in various contexts. This evidence concerns the gene CD4 and infection.