Summarized results of the CD4/CD8 ratio for the CD45+/CD3+-gated subsets among PBMCs from 11 HIV-1-infected and 8 uninfected hNOK/B51Tg mice showed that the CD4/CD8 ratio for HIV-1-infected hNOK/B51Tg mice was significantly decreased from 2 weeks post-infection as compared with that determined for the uninfected ones (Figure 1F). The gene discussed is CD4; the disease is infection.