Treatment with antibiotics that eliminate certain members of the commensal microbiota abrogates spontaneous colitis in Il10R2/TGFBR2 double knockout mice, but colitis recurs when these mice are inoculated with murine isolates of Bacteroides spp., especially B. theta and Bacteroides vulgatus, but not E. coli[18]. This evidence concerns the gene IL10RB and colitis.