The suppression of anti-lymphoma immunity by iNKT cells was previously observed using the RMA/S T cell lymphoma, but was in that case dependent on experimentally increasing expression of CD1d on lymphoma cells, which lead to a modest increase in overall survival of CD1d−/− and Jalpha18−/− mice compared to WT mice following tumor challenge [36]. Here, CD1D is linked to T-cell non-Hodgkin lymphoma.