Interestingly, while there was reduced tumor growth in CD3ε−/− and TCRβ−/− mice (Figure 1), which both lack iNKT cells and CD8+ T cells, this did not seem to be mediated by increased NK cell activity, as depletion of NK cells in TCRbeta−/− mice had no effect on tumor growth (Data not shown). This evidence concerns the gene CD3E and neoplasm.