The identification of iNKT cell suppression of the CD8+ T cell response to lymphoma is in agreement with previous work demonstrating that iNKT cells are suppressive in several autoimmune models such as rheumatoid arthritis, experimental autoimmune encyphalomyelitis (EAE) [26], and type I diabetes [27] (reviewed in [2]). Here, CD8A is linked to rheumatoid arthritis.