To find out whether the absence of iNKT cells affected the CD8+ T cell response to OVA in a context outside of lymphoma growth, we intravenously immunized WT and Jalpha18−/− mice with either 105 TBL-OVA cells or 105 OVA-peptide pulsed bone marrow derived dendritic cells (BMDC) and assessed the OVA-specific CD8+ T cell response in the spleen 8 days later. This evidence concerns the gene CD8A and lymphoma.