When rictor was immunoprecipitated in A375 melanoma cells, BRAF was detected in the rictor complex, in addition to mTOR and sin1 (core components of mTORC2), but not raptor (a component of mTORC1), suggesting that BRAFV600E may interact with mTORC2 directly (Fig. 5A). This evidence concerns the gene MAPKAP1 and melanoma.