Also, the recombinant adeno-associated virus-mediated transfer of the human catalase gene in the optic nerves of SJL/J mice with encephalomyelitis was found to reduce demyelination by 38%, optic nerve head swelling by 29%, cellular infiltration by 34%, disruption of the blood–brain barrier by 64%, and in vivo levels of H2O2 by 61% [56], and the adenovirus-mediated delivery of catalase to RPE cells in vitro and in vivo also protected RPE and the neighboring photoreceptors from oxidative stress [57]. The gene discussed is CAT; the disease is encephalomyelitis.