Positive expression of USP22 were significantly correlated with primary tumor site (χ2 = 51.321, P<0.001), tumor size (χ2 = 15.868, P<0.001), differentiation (χ2 = 50.029, P<0.001), T classification (χ2 = 77.196, P<0.001), N classification(χ2 = 44.599, P<0.001), M classification (χ2 = 21.743, P<0.001), AJCC stage (χ2 = 108.994, P<0.001), Ki-67 status (χ2 = 24.685, P<0.001), and COX-2 status (χ2 = 17.174, P<0.001). Here, USP22 is linked to neoplasm.