TP53 and breast carcinoma: In the WAP-TNP8 model, time-course analyses of p53 inhibition by means of SV40 large T-antigen expression (1, 2, 3, 4 and 5 months) showed a progressive increase in the overexpression of already overexpressed (plus a reduction in the expression of already underexpressed) 682-signature genes in mammary carcinomas (Fig. 2A).