We previously reported that a 682-gene expression signature common to two skin carcinoma models lacking p53 (alone or combined with a lack of pRb, hereafter referred to as p53ΔEC and p53ΔEC;pRbΔEC respectively) in stratified epithelia [12], [13] showed strong similarities to signatures of human primary carcinomas involving TP53 mutations (both truncating and point) arising in different anatomical locations. This evidence concerns the gene TP53 and skin carcinoma.