IRF5 and infection: Biofilm infections in MyD88 KO animals were associated with a significant reduction in the number of infiltrating macrophages at day 7 post-infection (Fig. 7), which were biased towards an anti-inflammatory/pro-fibrotic phenotype as revealed by a significant increase in CD206+ expression concomitant with decreased IRF-5+ levels (Fig. 8A and B, respectively).