SPARC and neoplasm: Using both two anti-SPARC antibody in normal ovarian tissues, SPARC expressions were low and mainly focused around the vasculatures in the stroma (Figure 2A and 2F), and in benign ovarian tumors, SPARC expression was also low and mainly focused not only in the stroma but also in the tumor cell cytoplasm (Figure 2B and 2G), finally in most ovarian carcinomas, the immunoreactivity was high, and high SPARC expression was found not only in stroma but also in the cytoplasm of ovarian cancer cells (Figure 2CDE and 2HIJ).