OPTN and open-angle glaucoma: Three causative genes have been identified thus far: optineurin (OPTN, OMIM 602432) on chromosome 10p14-15 [18], [26], myocilin (MYOC, OMIM 610652) on chromosome 1q24-25 [27]–[28], and WDR36 (OMIM 609669) on chromosome 5q21-22 [29], [30], but these account for fewer than 10% of patients with sporadic, adult-onset POAG.