On the other hand, there are also many instances where the correlation is less straightforward; this is illustrated by the role of FGFR3 in superficial urothelial carcinoma and spermatocytic seminoma, for both of which mutations and antibody positivity are described, but the correlation between the two is not absolute [11], [50]. This evidence concerns the gene FGFR3 and spermatocytic seminoma.