Selected examples include studies in which the cellular distribution of staining with an antibody to p53 in skin was shown to correlate with p53 mutational status [46], [47]; the correlation of change in histopathological characteristics and tumour mutational load revealed by deep sequencing [48]; and, directly relevant to this work, the demonstration in myelodysplastic syndrome that positivity for an FGFR3 antibody correlated with the presence of a t(4;14) translocation involving FGFR3 on chromosome 4 [49]. The gene discussed is FGFR3; the disease is myelodysplastic syndrome.