A stronger association of SNP rs2046210 with ER− tumours is also consistent with the report from the Consortium of Modifiers of BRCA1/2 (CIMBA) [7] that the same allele is associated with an increased Hazard Ratio of breast cancer in BRCA1 mutation carriers (who predominantly develop ER− tumours). Here, BRCA1 is linked to breast carcinoma.