One previous study have shown the antitumor DNA topoisomerase I (Top1) inhibitor camptothecin (CPT) increases the cellular levels of two antisense lncRNAs at the 5′ (5′aHIF-1α) and 3′ (3′aHIF-1α) ends of the human HIF-1α gene, they also proved the two antisense lncRNAs at the 5′ (5′aHIF-1α) and 3′ (3′aHIF-1α) that induced nuclear membrane trafficking and response to partially different kinds of stress expressed in human kidney cancer tissues [42]. This evidence concerns the gene TOP1 and kidney cancer.