The data presented in Figure 5A and B demonstrate that all VLP vaccines are capable of inducing the strong Th-2 responses in mice upon stimulation with whole viral antigens of either homologous H5N1 or heterologous PR8 strain, whereas only the H5M2eN1-VLP vaccine can induced detectable level of IFN-γ response when heterologous viral stimulation or infection. The gene discussed is IFNG; the disease is infection.