Consistent with previously reported literature [20], [21], [34]kl/kl mice showed a distinct premature aging phenotype, including emphysema, generalized atrophy of the skin, spleen, intestine, skeletal muscle, reproductive organs, and infertility, which was also evident in Dmp1−/−kl/kl animals (data not shown). The gene discussed is DMP1; the disease is pulmonary emphysema.