SMPD1 and breast adenocarcinoma: A number of studies have also linked ASM to cytoskeletal control: Zeidan et al elegantly demonstrated that cisplatin-induced cytoskeletal remodeling in MCF-7 breast adenocarcinoma cells was mediated by transient activation of ASM, which in turn caused dephosphorylation (inhibition) of another actin-binding protein, ezrin (at threonine 567) [45].