Similarly, mutations in the MT-ND5 gene are typically associated with a wide range of phenotypes, an example of which is the mutation m.13042G>A that is associated with both LHON and MELAS in the same maternal lineage, or may lead to overlapping MELAS/MERRF (Myoclonic Epilepsy, Ragged-Red Fibers) phenotypes or Leigh syndrome [31]–[33]. The gene discussed is MT-ND5; the disease is MELAS.