Analysis of the influence of chromatin-remodeling and histone-modifying complexes on p53-dependent activation of transcription in yeast revealed many similarities between transcriptional control by p53 in yeast and human cells [53], and nowadays yeast serves as a valuable tool for functional analysis of separated tumor-derived p53 alleles (FASAY) [54], [55], [56]. Here, TP53 is linked to neoplasm.