IL-1α represents a molecule with pleiotropic effects on a wide range of cell types [31] and has been extensively studied for its ability to contribute to various human autoimmune and inflammation-linked disorders, including rheumatoid arthritis, Alzheimer’s disease, systemic sclerosis and cardiovascular disorders [32], [33], [34], [35]. This evidence concerns the gene IL1A and early-onset autosomal dominant Alzheimer disease.