Many studies have shown that in more advanced HIV-1 infection, immune cells express pro-apoptotic markers [9]–[11], the strength and breadth of immune response to HIV-1 antigens decreases [50], immune effector cells are activated even without T-cell receptor (TCR) stimulation [15], and less APOBEC3G is expressed than in recently infected or exposed uninfected individuals [51]. This evidence concerns the gene APOBEC3G and HIV-1 infection.