But another recent study, by deleting ephrinB2 in Nav1.8+ nociceptive sensory neurons, indicates that presynaptic ephrinB2 expression may play a role in regulating inflammatory pain and some types of neuropathic pain through the regulation of synaptic plasticity in the DH [38].In conclusion, to date, we could confirm that the forword signaling produced by EphBs activation was involved in hyperalgesia induced by activation of ephrinBs/EphBs signaling. Here, EFNB2 is linked to neuropathic pain.